Chapter II
Neoplasms
(C00-D48)

Rules Conventions GCS DChS.II.1 DChS.II.2 DChS.II.4 Guidance

Neoplasms of uncertain or unknown behaviour
(D37-D48)

Note:

Categories D37-D48 classify by site neoplasms of uncertain or unknown behaviour, i.e., there is doubt whether the neoplasm is malignant or benign.

D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
DCS.II.12 DCS.XIII.4

D37.0 Lip, oral cavity and pharynx
Incl.:
Aryepiglottic fold:
  • NOS
  • hypopharyngeal aspect
  • marginal zone
Major and minor salivary glands
Vermilion border of lip
Excl.:
aryepiglottic fold, laryngeal aspect ( D38.0)
epiglottis:
skin of lip ( D48.5)
D37.1 Stomach
D37.2 Small intestine
D37.3 Appendix
D37.4 Colon
D37.5 Rectum
Incl.:
Rectosigmoid junction
D37.6 Liver, gallbladder and bile ducts
Incl.:
Ampulla of Vater
D37.7 Other digestive organs
Incl.:
Anal:
  • canal
  • sphincter
Anus NOS
Intestine NOS
Oesophagus
Pancreas
Excl.:
anal:
perianal skin ( D48.5)
D37.9 Digestive organ, unspecified

D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
DCS.II.12 DCS.XIII.4

Excl.:
heart ( D48.7)
D38.0 Larynx
Incl.:
Aryepiglottic fold, laryngeal aspect
Epiglottis (suprahyoid portion)
Excl.:
aryepiglottic fold:
D38.1 Trachea, bronchus and lung
D38.2 Pleura
D38.3 Mediastinum
D38.4 Thymus
D38.5 Other respiratory organs
Incl.:
Accessory sinuses
Cartilage of nose
Middle ear
Nasal cavities
Excl.:
ear (external)(skin) ( D48.5)
nose:
D38.6 Respiratory organ, unspecified

D39 Neoplasm of uncertain or unknown behaviour of female genital organs
DCS.II.12 DCS.XIII.4

D39.0 Uterus
D39.1 Ovary
D39.2 Placenta
Incl.:
Chorioadenoma destruens
Hydatidiform mole:
  • invasive
  • malignant
Excl.:
hydatidiform mole NOS ( O01.9)
D39.7 Other female genital organs
Incl.:
Skin of female genital organs
D39.9 Female genital organ, unspecified

D40 Neoplasm of uncertain or unknown behaviour of male genital organs
DCS.II.12 DCS.XIII.4

D40.0 Prostate
D40.1 Testis
D40.7 Other male genital organs
Incl.:
Skin of male genital organs
D40.9 Male genital organ, unspecified

D41 Neoplasm of uncertain or unknown behaviour of urinary organs
DCS.II.12 DCS.XIII.4

D41.0 Kidney
Excl.:
renal pelvis ( D41.1)
D41.1 Renal pelvis
D41.2 Ureter
D41.3 Urethra
D41.4 Bladder
D41.7 Other urinary organs
D41.9 Urinary organ, unspecified

D42 Neoplasm of uncertain or unknown behaviour of meninges
DCS.II.12 DCS.XIII.4

D42.0 Cerebral meninges
D42.1 Spinal meninges
D42.9 Meninges, unspecified

D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
DCS.II.12 DCS.XIII.4

Excl.:
peripheral nerves and autonomic nervous system ( D48.2)
D43.0 Brain, supratentorial
Incl.:
Cerebral ventricle
Cerebrum
  • Frontal
  • Occipital
  • Parietal
  • Temporal
  • lobe
Excl.:
fourth ventricle ( D43.1)
D43.1 Brain, infratentorial
Incl.:
Brain stem
Cerebellum
Fourth ventricle
D43.2 Brain, unspecified
D43.3 Cranial nerves
D43.4 Spinal cord
D43.7 Other parts of central nervous system
D43.9 Central nervous system, unspecified
Incl.:
Nervous system (central) NOS

D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
DCS.II.12 DCS.XIII.4

Excl.:
endocrine pancreas ( D37.7)
ovary ( D39.1)
testis ( D40.1)
thymus ( D38.4)
D44.0 Thyroid gland
D44.1 Adrenal gland
D44.2 Parathyroid gland
D44.3 Pituitary gland
D44.4 Craniopharyngeal duct
D44.5 Pineal gland
D44.6 Carotid body
D44.7 Aortic body and other paraganglia
D44.8 Pluriglandular involvement
Incl.:
Multiple endocrine adenomatosis
D44.9 Endocrine gland, unspecified

D45 Polycythaemia vera
DCS.II.12 DCS.XIII.4

Note:
Polycythaemia vera has been reclassified in ICD-O Third Edition with a malignant code. The code D45 will continue to be used, although it is located in the chapter for Neoplasms of uncertain or unknown behaviour. The modification of its classification is reserved to the revision of ICD.

D46 Myelodysplastic syndromes
DCS.II.12 DCS.XIII.4

Incl.:
Alkylating-agent-related myelodysplastic syndrome
Epipodophyllotoxin-related myelodysplastic syndrome
Therapy-related myelodysplastic syndrome NOS
Excl.:
drug induced aplastic anaemia ( D61.1)
D46.0 Refractory anaemia without ring sideroblasts, so stated
Note:
without sideroblasts, without excess of blasts
D46.1 Refractory anaemia with ring sideroblasts
D46.2 Refractory anaemia with excess of blasts [RAEB]
Note:
RAEB I
RAEB II
D46.4 Refractory anaemia, unspecified
D46.5 Refractory anaemia with multi-lineage dysplasia
D46.6 Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality
Incl.:
5 q-minus syndrome
D46.7 Other myelodysplastic syndromes
Excl.:
chronic myelomonocytic leukaemia ( C93.1)
D46.9 Myelodysplastic syndrome, unspecified
Incl.:
Myelodysplasia NOS
Preleukaemia (syndrome) NOS

D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
DCS.II.12 DCS.XIII.4

D47.0 Histiocytic and mast cell tumours of uncertain and unknown behaviour
Incl.:
Indolent systemic mastocytosis
Mast cell tumour NOS
Mastocytoma NOS
Systemic mastocytosis, associated with clonal haematopoietic non-mast-cell disease (SM-AHNMD)
Excl.:
mastocytosis (congenital) (cutaneous) ( Q82.2)
D47.1 Chronic myeloproliferative disease
Incl.:
Chronic neutrophilic leukaemia
Myeloproliferative disease, unspecified
Excl.:
atypical chronic myeloid leukaemia, BCR/ABL-negative ( C92.2)
chronic myeloid leukaemia [CML] BCR/ABL-positive ( C92.1)
D47.2 Monoclonal gammopathy of undetermined significance (MGUS)
D47.3 Essential (haemorrhagic) thrombocythaemia
Incl.:
Idiopathic haemorrhagic thrombocythaemia
D47.4 Osteomyelofibrosis
Incl.:
Chronic idiopathic myelofibrosis
Myelofibrosis (idiopathic) (with myeloid metaplasia)
Myelosclerosis (megakaryocytic) with myeloid metaplasia
Secondary myelofibrosis in myeloproliferative disease
Excl.:
acute myelofibrosis ( C94.4)
D47.5 Chronic eosinophilic leukaemia [hypereosinophilic syndrome]
D47.7 Other specified neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
Incl.:
Histiocytic tumours of uncertain and unknown behaviour
D47.9 Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
Incl.:
Lymphoproliferative disease NOS

D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
DCS.II.12 DCS.XIII.4

Excl.:
neurofibromatosis (nonmalignant) ( Q85.0)
D48.0 Bone and articular cartilage
Excl.:
cartilage of:
connective tissue of eyelid ( D48.1)
synovia ( D48.1)
D48.1 Connective and other soft tissue
Incl.:
Connective tissue of:
  • ear
  • eyelid
Excl.:
cartilage (of):
connective tissue of breast ( D48.6)
D48.2 Peripheral nerves and autonomic nervous system
Excl.:
peripheral nerves of orbit ( D48.7)
D48.3 Retroperitoneum
D48.4 Peritoneum
D48.5 Skin
Incl.:
Anal:
  • margin
  • skin
Perianal skin
Skin of breast
Excl.:
anus NOS ( D37.7)
skin of genital organs ( D39.7, D40.7)
vermilion border of lip ( D37.0)
D48.6 Breast
Incl.:
Connective tissue of breast
Cystosarcoma phyllodes
Excl.:
skin of breast ( D48.5)
D48.7 Other specified sites
Incl.:
Eye
Heart
Peripheral nerves of orbit
Excl.:
connective tissue ( D48.1)
skin of eyelid ( D48.5)
D48.9 Neoplasm of uncertain or unknown behaviour, unspecified
Incl.:
"Growth" NOS
Neoplasm NOS
New growth NOS
Tumour NOS